Aggravated mucosal and immune damage in a mouse model of ulcerative colitis with stress
نویسندگان
چکیده
منابع مشابه
Ginkgo biloba attenuates mucosal damage in a rat model of ulcerative colitis.
Intestinal inflammatory states, regardless of specific initiating events, share common immunologically mediated pathways of tissue injury and repair. The efficacy of various drugs used to treat ulcerative colitis (UC) was investigated. The aim of the present study is to evaluate the effects of ginkgo biloba extract on the extent and severity of UC caused by intracolonic administration of acetic...
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Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease of unknown aetiology, although bacterial species belonging to the normal colonic microbiota are known to be involved in its initiation and maintenance. Several organisms have been linked to the disease; however, mucosa-associated bacteria are more likely to be involved than their luminal counterparts, due to their close ...
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The mechanism by which mucosal change is produced in ulcerative colitis is obscure. Once an attack of the disease has occurred, there is a tendency for the condition to persist or to relapse, and perhaps correlated with this is the fact that the mucosa may remain abnormal in the absence of active clinical disease. Truelove and Richards (1956) pointed out that more than 50% of patients in clinic...
متن کاملMucosal tears during colonoscopy in a patient with ulcerative colitis.
of bloody diarrhea. Except for partial gastroduodenectomy because of a duodenal ulcer, the subject was healthy and was not taking any regular medication. He had not recently visited any foreign countries. Physical examination was unremarkable. Routine laboratory tests and complete blood analysis were normal. Total colonoscopy was performed after standard bowel preparation, without sedation. Col...
متن کاملControversies in mucosal healing in ulcerative colitis.
As clinicians we would all agree that the goal for our patients is to induce remission, which is usually defined as symptom resolution. Restoring continence and absence of rectal bleeding would be signs that the mucosa is at most minimally inflamed if not healed. However, there have not been any data to confirm that symptomatic improvement alters the natural history of the disease, nor decrease...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2019
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2019.7162